abstract：BACKGROUND:Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions in the etiology of this symptom. Given that white matter fasciculi represent the anatomical inf...

journal_title：Schizophrenia research

authors： Whitford TJ,Kubicki M,Pelavin PE,Lucia D,Schneiderman JS,Pantelis C,McCarley RW,Shenton ME

更新日期：2015-01-01 00:00:00

abstract：:Speech deficits, notably those involved in psychomotor retardation, blunted affect, alogia and poverty of content of speech, are pronounced in a wide range of serious mental illnesses (e.g., schizophrenia, unipolar depression, bipolar disorders). The present project evaluated the degree to which these deficits manifes...

journal_title：Schizophrenia research

authors： Cohen AS,McGovern JE,Dinzeo TJ,Covington MA

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Numerous studies have examined a wide range of risk factors associated with violence among patients with schizophrenia. However, risk factors linked to different socio-cultural backgrounds remain unclear. OBJECTIVE:The objectives were to investigate factors associated with violence among Japanese patients w...

journal_title：Schizophrenia research

authors： Imai A,Hayashi N,Shiina A,Sakikawa N,Igarashi Y

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinica...

journal_title：Schizophrenia research

authors： Brandizzi M,Schultze-Lutter F,Masillo A,Lanna A,Curto M,Lindau JF,Solfanelli A,Listanti G,Patanè M,Kotzalidis G,Gebhardt E,Meyer N,Di Pietro D,Leccisi D,Girardi P,Fiori Nastro P

更新日期：2014-12-01 00:00:00

abstract：:In 1873 Skeffington Lutwidge, a Lunacy Commission inspector of asylums in England, was killed by an asylum patient. Lutwidge was the uncle and close friend of Charles Lutwidge Dodgson, also known as Lewis Carroll. One year later, Carroll began writing The Hunting of the Snark, a poem whose meaning has mystified Carrol...

journal_title：Schizophrenia research

authors： Torrey EF,Miller J

更新日期：2014-12-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) studies suggest abnormalities in the white matter microstructure of the fornix in schizophrenia patients. Research evaluating schizophrenia patient and relatives also suggests that the white matter microstructure of the fornix is heritable. However, previous studies have been hindered by...

journal_title：Schizophrenia research

authors： Goghari VM,Billiet T,Sunaert S,Emsell L

更新日期：2014-11-01 00:00:00

abstract：:Deficits in nonverbal vocal expression (e.g., blunted vocal affect, alogia) are a hallmark of schizophrenia and are a focus of the Research Domain Criteria initiative from the National Institute of Mental Health. Results from studies using symptom rating scales suggest that these deficits are profound; on the order of...

journal_title：Schizophrenia research

authors： Cohen AS,Mitchell KR,Elvevåg B

更新日期：2014-11-01 00:00:00

abstract：:Schizoaffective patients can have neurocognitive deficits and default mode network dysfunction while being acutely ill. It remains unclear to what extent these abnormalities persist when they go into clinical remission. Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also und...

journal_title：Schizophrenia research

authors： Madre M,Radua J,Landin-Romero R,Alonso-Lana S,Salvador R,Panicali F,Pomarol-Clotet E,Amann BL

更新日期：2014-11-01 00:00:00

abstract：:This randomized open-label study compared the incidence of metabolic side effects of aripiprazole, ziprasidone and quetiapine in a population of medication-naïve first-episode psychosis patients. A total of 202 subjects were enrolled. Body weight, body mass index, leptin, fasting lipids and fasting glycaemic parameter...

journal_title：Schizophrenia research

authors： Pérez-Iglesias R,Ortiz-Garcia de la Foz V,Martínez García O,Amado JA,Garcia-Unzueta MT,Ayesa-Arriola R,Suarez-Pinilla P,Tabares-Seisdedos R,Crespo-Facorro B

更新日期：2014-10-01 00:00:00

abstract：:Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy contr...

journal_title：Schizophrenia research

authors： Geoffroy PA,Houenou J,Duhamel A,Amad A,De Weijer AD,Curčić-Blake B,Linden DE,Thomas P,Jardri R

更新日期：2014-10-01 00:00:00

abstract：:First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...

journal_title：Schizophrenia research

authors： Scanlon C,Anderson-Schmidt H,Kilmartin L,McInerney S,Kenney J,McFarland J,Waldron M,Ambati S,Fullard A,Logan S,Hallahan B,Barker GJ,Elliott MA,McCarthy P,Cannon DM,McDonald C

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The study aimed to assess the construct validity, internal consistency and factor structure of the Specific Levels of Functioning Scale (SLOF), a multidimensional instrument assessing real life functioning. METHODS:The study was carried out in 895 Italian people with schizophrenia, all living in the communi...

journal_title：Schizophrenia research

authors： Mucci A,Rucci P,Rocca P,Bucci P,Gibertoni D,Merlotti E,Galderisi S,Maj M,Italian Network for Research on Psychoses.

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The aim of this study is to determine the rate of persistent negative symptoms according to different criteria during two years of follow-up after first-episode schizophrenia. METHODS:The study sample consisted of 105 patients with first-episode schizophrenia who completed at least 12 months of follow-up pe...

journal_title：Schizophrenia research

authors： Üçok A,Ergül C

更新日期：2014-09-01 00:00:00

abstract：:Stigma may undermine the well-being of young people at risk of psychosis. We therefore measured self-labeling, stigma variables and well-being at baseline and again one year later among 77 at-risk participants. An increase in self-labeling during this period predicted heightened stigma stress after one year and a decr...

journal_title：Schizophrenia research

authors： Rüsch N,Müller M,Heekeren K,Theodoridou A,Metzler S,Dvorsky D,Corrigan PW,Walitza S,Rössler W

更新日期：2014-09-01 00:00:00

abstract：:Cortical thickness may be useful as a treatment response predictor in first-episode (FE) patients with schizophrenia, although this possibility has been scarcely assessed. In this study we assessed the possible relation between cortical thickness in regions of interest selected because of previously reported structura...

journal_title：Schizophrenia research

authors： Molina V,Taboada D,Aragüés M,Hernández JA,Sanz-Fuentenebro J

更新日期：2014-09-01 00:00:00

abstract：:Affect perception has frequently been shown to be impaired in patients suffering from schizophrenia or bipolar disorder (BD), but it remains unclear whether these impairments exist during symptomatic remission and whether the two disorders differ from each other in this regard. Most previous studies have investigated ...

journal_title：Schizophrenia research

authors： Hoertnagl CM,Yalcin-Siedentopf N,Baumgartner S,Biedermann F,Deisenhammer EA,Hausmann A,Kaufmann A,Kemmler G,Mühlbacher M,Rauch AS,Fleischhacker WW,Hofer A

更新日期：2014-09-01 00:00:00

abstract：:The ubiquitin ligase F-box protein 45 (FBXO45) is critical for synaptogenesis, neuronal migration, and synaptic transmission. FBXO45 is included in the 3q29 microdeletion region that confers a significant risk for schizophrenia, as shown by rare structural variant studies. Thus, FBXO45 is considered a prominent candid...

journal_title：Schizophrenia research

authors： Wang C,Koide T,Kimura H,Kunimoto S,Yoshimi A,Nakamura Y,Kushima I,Banno M,Kawano N,Takasaki Y,Xing J,Noda Y,Mouri A,Aleksic B,Ikeda M,Okada T,Iidaka T,Inada T,Iwata N,Ozaki N

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Depressive symptoms frequently accompany schizophrenia. Older patients constitute the fastest growing segment of the schizophrenia population. With regard to the risk factors associated with depression, it is uncertain to which extent older schizophrenia patients differ from their age peers in the community....

journal_title：Schizophrenia research

authors： Meesters PD,Comijs HC,Sonnenberg CM,Hoogendoorn AW,de Haan L,Eikelenboom P,Beekman AT,Stek ML

更新日期：2014-08-01 00:00:00

abstract：:Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...

journal_title：Schizophrenia research

authors： Smith GC,Zhang ZY,Mulvey T,Petersen N,Lach S,Xiu P,Phillips A,Han W,Wang MW,Shepherd PR

更新日期：2014-08-01 00:00:00

abstract：:Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. The therapeutic effect of these drugs is dependent upon the dopaminergic D2 blockade, but they also modulate other neurotransmitter pathways. The exact mechanisms underlying the clinical response to APDs are not fully understood. In this study, w...

journal_title：Schizophrenia research

authors： Santoro ML,Ota VK,Stilhano RS,Silva PN,Santos CM,Diana MC,Gadelha A,Bressan RA,Melaragno MI,Han SW,Abílio VC,Belangero SI

更新日期：2014-08-01 00:00:00

abstract：:Enhancing work function is now widely considered a core element of comprehensive schizophrenia treatment. While research efforts have illuminated factors that influence how well patients perform at work, less is known about the factors influencing the subjective experience of work. It is not known how, and to what ext...

journal_title：Schizophrenia research

authors： de Jong S,Renard SB,van Donkersgoed RJ,van der Gaag M,Wunderink L,Pijnenborg GH,Lysaker PH

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:We aimed to examine the association between illicit substance use and age at onset in psychotic disorders in an Australian cohort. METHODS:Retrospectively acquired information on substance use during the year prior to illness onset was collected from 1642 participants enrolled in the Australian National 201...

journal_title：Schizophrenia research

authors： Stefanis NC,Dragovic M,Power BD,Jablensky A,Castle D,Morgan VA

更新日期：2014-07-01 00:00:00

abstract：:Individuals with psychotic illnesses are known to have a reduced fertility. It is unclear whether this is due to biological or social factors. Most fertility studies have been conducted in chronic schizophrenia, where confounders like medication and hospitalisation make this difficult to elicit. A less severe reductio...

journal_title：Schizophrenia research

authors： Zimbron J,Stahl D,Hutchinson G,Dazzan P,Morgan K,Doody GA,Jones PB,Murray RM,Fearon P,Morgan C,MacCabe JH

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:The impact of cannabis use on the brain tissue is still unclear, both in the healthy developing brain and in people with schizophrenia. The focus of this review is on white matter, the primary connective infrastructure of the brain. METHODS:We systematically reviewed diffusion tensor imaging (DTI) studies o...

journal_title：Schizophrenia research

authors： Cookey J,Bernier D,Tibbo PG

更新日期：2014-07-01 00:00:00

abstract：:Self-determination theory (SDT) provides a model for understanding motivation deficits in schizophrenia, and recent research has focused on problems with intrinsic motivation. However, SDT emphasizes that motivated behavior results from three different factors: intrinsic motivators (facilitated by needs for autonomy, ...

journal_title：Schizophrenia research

authors： Gard DE,Sanchez AH,Starr J,Cooper S,Fisher M,Rowlands A,Vinogradov S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Studies in healthy individuals show that exerting self-control consumes cognitive resources, which reduces subsequent self-control performance. Restoring the availability of blood glucose eliminates this impairment. Patients with schizophrenia are found to have self-regulatory dysfunctions. This study aims to...

journal_title：Schizophrenia research

authors： Leung CM,Stone WS,Lee EH,Seidman LJ,Chen EY

更新日期：2014-06-01 00:00:00

abstract：:Cognitive adaptation training (CAT) is a home-based, manualized treatment that utilizes environmental supports to improve target behaviors and functional outcomes in persons with schizophrenia. Although clinical trials have shown CAT to be effective across functional, clinical, and treatment adherence domains, when th...

journal_title：Schizophrenia research

authors： Kidd SA,Herman Y,Barbic S,Ganguli R,George TP,Hassan S,McKenzie K,Maples N,Velligan D

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Cognitive remediation (CR) aims primarily to improve cognition and functional outcomes. However, a limited number of studies reported a positive effect on symptoms. This limited effect may be because the symptom clusters considered are too broad and heterogeneous. This study explores, for the first time, the...

journal_title：Schizophrenia research

authors： Cella M,Reeder C,Wykes T

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research. METHODS:The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleo...

journal_title：Schizophrenia research

authors： Yeo RA,Gangestad SW,Walton E,Ehrlich S,Pommy J,Turner JA,Liu J,Mayer AR,Schulz SC,Ho BC,Bustillo JR,Wassink TH,Sponheim SR,Morrow EM,Calhoun VD

更新日期：2014-06-01 00:00:00

abstract：:Impaired illness insight in schizophrenia is associated with non-adherence and worse outcomes. Schizophrenia patients also exhibit error-monitoring deficits, which have been proposed to cause poor insight. To test this hypothesis, we examined whether schizophrenia patients' deficits in neurophysiological error-monitor...

journal_title：Schizophrenia research

authors： Kansal V,Patriciu I,Kiang M

更新日期：2014-06-01 00:00:00

abstract：:Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudde...

journal_title：Schizophrenia research

authors： Ifteni P,Correll CU,Burtea V,Kane JM,Manu P

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:While the functional disconnectivity hypothesis of schizophrenia has received considerable attention, fewer studies have investigated the contribution of genotype to structural connectivity between brain regions either in schizophrenia patients or in healthy controls. In this study, we obtained diffusion ten...

journal_title：Schizophrenia research

authors： Mounce J,Luo L,Caprihan A,Liu J,Perrone-Bizzozero NI,Calhoun VD

更新日期：2014-05-01 00:00:00

abstract：:Schizophrenia is associated with impairments in social interactions, and the conditions under which patients live and undergo treatment appear to have an important role in the course of the disease. However, the influences of care settings on the course of cognition remain controversial. The closure of psychiatric hos...

journal_title：Schizophrenia research

authors： Nemoto T,Niimura H,Ryu Y,Sakuma K,Mizuno M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The Heinrichs-Carpenter Quality of Life Scale (QLS) is the most extensively used real-world community functioning scale in schizophrenia research. However, the extensive time required to administer it and the inclusion of items that overlap conceptually with negative symptoms limit its use across studies. Th...

journal_title：Schizophrenia research

authors： Fervaha G,Foussias G,Siddiqui I,Agid O,Remington G

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. AIMS:The aim of this study is to investigate whether suicidal behaviors, including sui...

journal_title：Schizophrenia research

authors： Witt K,Hawton K,Fazel S

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:To identify the determinants of schizophrenia-specific HRQoL levels, five types of factors (i.e., sociodemographic, clinical, psychopathological, neurocognitive, and psychosocial factors) were simultaneously investigated in the same cross-sectional sample. METHODS:A total of 120 patients with a diagnosis of sc...

journal_title：Schizophrenia research

authors： Chou CY,Ma MC,Yang TT

更新日期：2014-04-01 00:00:00

abstract：:In a 12-week randomized open-label trial, adults diagnosed with schizophrenia experiencing inadequate efficacy and/or poor tolerability on risperidone, olanzapine, or aripiprazole were randomized to switch to iloperidone either gradually (ie, down-titration of current therapy over the first 2weeks [to 50% on Day 1, 25...

journal_title：Schizophrenia research

authors： Weiden PJ,Citrome L,Alva G,Brams M,Glick ID,Jackson R,Mattingly G,Kianifard F,Meng X,Pestreich L,Hochfeld M,Winseck A

更新日期：2014-03-01 00:00:00

abstract：:Assessment of depression in individuals who are considered to be at clinical high risk (CHR) for psychosis is important as high rates of depression have been reported in CHR individuals. The Calgary Depression Scale (CDSS) is the most widely used scale for assessing depression in schizophrenia. It has excellent psycho...

journal_title：Schizophrenia research

authors： Addington J,Shah H,Liu L,Addington D

更新日期：2014-03-01 00:00:00

abstract：:Evidence-based decisions on indicated prevention in early psychosis require large-scale studies on the pathways to care in high-risk subjects. EPOS (The European Prediction of Psychosis Study), a prospective multi-center, naturalistic field study in four European countries (Finland, Germany, The Netherlands and Englan...

journal_title：Schizophrenia research

authors： von Reventlow HG,Krüger-Özgürdal S,Ruhrmann S,Schultze-Lutter F,Heinz A,Patterson P,Heinimaa M,Dingemans P,French P,Birchwood M,Salokangas RK,Linszen D,Morrison A,Klosterkötter J,Juckel G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and healthy comparison subjects (HCS). The Consortium on the Genetics of Schizophrenia (COGS) identified associations between PPI and single nucleotide polymorphisms in schizoph...

journal_title：Schizophrenia research

authors： Swerdlow NR,Light GA,Sprock J,Calkins ME,Green MF,Greenwood TA,Gur RE,Gur RC,Lazzeroni LC,Nuechterlein KH,Radant AD,Ray A,Seidman LJ,Siever LJ,Silverman JM,Stone WS,Sugar CA,Tsuang DW,Tsuang MT,Turetsky BI,Braff D

更新日期：2014-02-01 00:00:00